Signal Transduction by Metastable Molecular Complexes: Findings by Single-Molecule Tracking
نویسندگان
چکیده
منابع مشابه
Single-Molecule Kinetic Analysis of Stochastic Signal Transduction Mediated by G-Protein Coupled Chemoattractant Receptors
Cellular chemotactic behaviors are typical examples of stochastic signal transduction in living cells that have been investigated in detail both experimentally and theoretically. In this chapter, we describe single-molecule kinetic analysis for stochastic signal transduction in chemotactic responses mediated by G proteincoupled chemoattractant receptors in order to give deeper understanding of ...
متن کاملHedgehog signal transduction: recent findings.
The Hedgehog (Hh) family of signaling molecules are key agents in patterning numerous types of tissues. Mutations in Hh and its downstream signaling molecules are also associated with numerous oncogenic and disease states. Consequently, understanding the mechanisms by which Hh signals are transduced is important for understanding both development and disease. Recent studies have clarified sever...
متن کاملTracking molecular resonance forms of donor–acceptor push–pull molecules by single-molecule conductance experiments
The ability of molecules to change colour on account of changes in solvent polarity is known as solvatochromism and used spectroscopically to characterize charge-transfer transitions in donor-acceptor molecules. Here we report that donor-acceptor-substituted molecular wires also exhibit distinct properties in single-molecule electronics under the influence of a bias voltage, but in absence of s...
متن کاملThe complexity of complexes in signal transduction.
Many activities of cells are controlled by cell-surface receptors, which in response to ligands, trigger intracellular signaling reactions that elicit cellular responses. A hallmark of these signaling reactions is the reversible nucleation of multicomponent complexes, which typically begin to assemble when ligand-receptor binding allows an enzyme, often a kinase, to create docking sites for sig...
متن کاملBRCA Testing by Single-Molecule Molecular Inversion Probes.
BACKGROUND Despite advances in next generation DNA sequencing (NGS), NGS-based single gene tests for diagnostic purposes require improvements in terms of completeness, quality, speed, and cost. Single-molecule molecular inversion probes (smMIPs) are a technology with unrealized potential in the area of clinical genetic testing. In this proof-of-concept study, we selected 2 frequently requested ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.071